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Strategies to enhance the tolerability of GLP-1-based therapy might include identification of agents that stimulate release of endogenous GLP-1 from intestinal L-cells, potentially accompanied by fewer adverse effects

Generally, after 812 weeks of continuous use, a 4-week washout period is required to avoid tolerance from long-term continuous use

The findings illustrate a recurring observation in IGF-1 LR3 research: mass-level effects do not necessarily translate to functional recovery, and delivery kinetics appear to be a critical variable in study outcomes

Studies link it to the hallmarks of extreme dieting: caloric deficits that cause iron, protein, zinc, and biotin shortages and hormonal shifts like elevated cortisol levels and/or insulin fluctuations

[PubMed 19604213] 4