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Intrinsic sources include the mitochondria, which are a major source of ROS during the process of oxidative phosphorylation

doi: 10.1186/s12990-015-0009-2 [DOI] [PMC free article] [PubMed] [Google Scholar] 19.Di Cesare Mannelli L, Ghelardini C, Calvani M, et al

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Cells were transfected with plasmids for expression of different gB homologues, namely HSV-1, HSV-2, VZV, HCMV or EBV

It is suggested that this feedback loop between initial hyperactivation, hypophysitis/pituitary hypopituitarism and immune depletion may contribute to the development and persistence of LC and other infectious syndromes such as ME/CFS