This is not normal, healthy weight loss
Viability was assessed by Zombie UV Fixable Viability Dye (BioLegend) and cytokine production was measured by intracellular cytokine staining after 3 h stimulation with PMA (50 ng ml 1 ) (BioGems) and ionomycin (1 g ml 1 ) (BioGems) in the presence of brefeldin A (1 g ml 1 ) (GolgiPlug, BD Biosciences)
Tirzepatide is more extensively studied, has regulatory approval for specific indications, and may be preferred for studies requiring a more established evidence base
Congenital & Chromosomal Conditions Down syndrome (Q90.x): Trisomy 21 results in characteristic facial features, hypotonia, intellectual disability, and substantially elevated risk for congenital heart defects (4050%, most commonly AVSD), leukemia, and hypothyroidism
Wegovy 0.5 mg, FlexTouch solution for injection in pre-filled pen Summary of Product Characteristics