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Participants with type 2 diabetes were randomized to once-weekly semaglutide versus placebo

Study population and eligibility criteria We reasoned to choose as patients cohort a group of healthy obese women with polycystic ovary syndrome (PCOS) that have increased metabolic risk, in order to avoid any other concomitant clinical feature as a confounding factor, and potentially affecting the results of our study

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The American College of Gastroenterology's 2021 guideline on irritable bowel syndrome management issued a conditional recommendation against the use of probiotics for global IBS symptoms, citing very low overall quality of evidence.[8] IBS is not the same as GLP-1 constipation, but it overlaps in terms of dysmotility-driven symptoms, and the guideline tone signals appropriate caution about probiotic claims in this neighborhood