Role of HDACs in epilepsy Although the pathogenesis of epilepsy has not been fully established, excitotoxicity, oxidative stress and neuroinflammation are regarded as the triads of epileptogenesis, a process during which triggers of brain insults such as status epilepticus by chemoconvulsants, infection or cerebrovascular disease include and the brain undergoes a cascade of morphological and functional changes prior to the onset of spontaneous recurrent seizures in chronic epilepsy [98], and epilepsy-associated neurodegeneration
Francavilla S, Properzi G, Bellini C, Marino G, Ferri C, Santucci A
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In summary, immune dysfunction in UC comprises exaggerated effector responses coupled with defective regulatory control