does glp-1 make you lose weight Medications: Is Ozempic the Best Option for You? How GLP-1 Medications Boost Weight

29 In a study involving 1,306 overweight or obese individuals receiving 2.4 mg of semaglutide, approximately 6% and 12% weight loss was observed at 12 and 28 weeks, respectively, and total fat mass decreased by approximately 20% after 56 weeks of treatment

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10.3390/ijms25158355 248 XieJ.YangY.ZhuoA.GaoM.TangL.XiaoY.et al (2024)

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The mechanistic comparison is particularly interesting: CagriSema adds amylin signaling to GLP-1, while retatrutide adds glucagon and GIP signaling