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An early GLP-1 drug, Exendin-4, was found to reduce conditioned place preference and dopamine release in the nucleus accumbens in response to nicotine, cocaine, and amphetamine (a brain region that is understood to play a crucial role in the bodys reward system) as well as to reduce cocaine self-administration and seeking behavior in rats

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Only some GLP-1s are included The covered medications include drugmaker Eli Lilly's Foundayo oral tablets and Zepbound KwikPens and Novo Nordisk's Wegovy injections and tablets