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Consequently, intracellular zinc homeostasis alterations regulate downstream molecular objectives, in addition to protein kinase C (PKC), ERK1/2 activation leading to neuronal cell death, cAMP-dependent protein kinase (PKA), Ca/calmodulin-dependent protein kinase II (CaMKII), phosphodiesterases (PDEs), protein tyrosine phosphatases (PTPs), and transcription factors, such as NF-B

Additionally, we perform global sensitivity analysis to examine which pathways have the greatest impact on ROS and the GSH redox system in control compared to RP conditions

Two identical Phase III studies, TRONTIER 1 and 2, are underway to evaluate the efficacy and safety in people with early symptomatic Alzheimers disease

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(PubMed)