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PT-141 was developed specifically because Melanotan-2's indiscriminate melanocortin receptor activation (including MC1R) produced tanning as a side effect in men voluntarily testing it in Arizona, where tanning is common but was not the intended study outcome

There's little scientific evidence to suggest that GLP-1 patches work for weight loss , and they certainly can't compete with clinically approved GLP-1 injections

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Biochemically modified for enhanced potency and sustained action, GLP-1 receptor agonists are successfully in clinical use for the treatment of type-2 diabetes, and several GLP-1-based pharmacotherapies are in clinical evaluation for the treatment of obesity

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