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The modulatory mechanism of ZXGD on cholesterol metabolism may involve upregulating HDL-C, downregulating TC and LDL-C in serum, promoting storage of cholesterol esters in LDs, and restoring counts of LDs in PASMCs, thus maintaining cholesterol metabolic homeostasis and enhancing cellular detoxification [60], thereby inhibiting lipid metabolism driving factors for pulmonary vascular remodeling in PH rats

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