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It is produced using recombinant DNA technology, which replicates the human growth hormone sequence, and gives it the common name recombinant hGH (rhGH) [9]

In addition, in OA chondrocytes, the decrease in the activity of respiratory chain complexes I, II and III may affect several pathways related to cartilage degradation, including oxidative stress, biosynthesis of chondrocytes, increased inflammation and matrix catabolism induced by cytokines, calcification of cartilage matrix and increased apoptosis of cartilage cells (Blanco et al., 2011)

Annals of Epidemiology , 30

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