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The Journal of Cinical Endocrinology and Metabolism

RetatrutideA game changer in obesity Pharmacotherapy Summary: Retatrutide is currently undergoing extensive Phase 3 clinical trials (the TRIUMPH program), evaluating its efficacy and safety in diverse populations, including those with obesity, type 2 diabetes, established cardiovascular disease, and knee osteoarthritis

A Guide to Weight-Loss Medications: Anti-obesity drugs, from older pills to the new GLP-1s Losing weight is hard to do

2021 study (PMID: 33996787) demonstrated selectivity in human chondrocyte cultures, but long-term effects on stem cell niches have not been systematically studied

However, the mechanism of metabolic dysregulation in affecting the progress and disease severity of SCD has not been well characterized, especially when exposed to excess hemin