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E) Fluo-4-loaded HEK-GLP-1R cells were challenged with vehicle control (1% DMSO), a concentration of either compound 2 (10 M) or GLP-1 936 amide (1 M) established to have little effect on [Ca2+]i or alternatively, compound 2 (10 M) and GLP-1 936 amide (1 M) in combination

found another degradation mechanism of TAGs in LDs, referred to as lipophagy, which is the primary lipid removal pathway in the liver [75], and was subsequently also found in neurons, macrophages, and tumor cells

Proteomics data were normalized using an iterative Combat normalization to adjust for batch effects within each data layer