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Unlike exogenous growth hormone, tesamorelin stimulates the pituitary gland to produce its own GH, which preserves the natural pulsatile release pattern and provides physiological feedback regulation that exogenous GH bypasses entirely

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We thus cultured cells in media with L-cystine but without L-glutamate, media lacking L-cystine and L-glutamate, or media lacking L-cystine but supplemented with L-glutamate (i.e., mimicking system x c - activity)