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Treatment with rhIGF-1 was shown to improve hydration status in children with GHR-insensitivity, further supporting the concept that the sodium and water-retaining properties of GH are at least partly mediated by IGF-1 ( vide supra ) [60]

7,72 Electrolyte Imbalance and Metabolic Acidosis The kidneys are responsible for controlling a broad range of essential mineral and fluid balances, including tightly regulating the retention and excretion of sodium and potassium while maintaining normal pH by balancing the acidity of urine, which impacts the blood and the whole body