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Retatrutide Side Effects Are Similar to Existing Diabetes and Obesity Injectables The most common side effects for retatrutide were: Nausea (16 to 27 percent of participants, depending on dosage, compared with 3.7 percent of those taking a placebo) Diarrhea (19 to 23 percent, compared with 5 percent taking a placebo) Vomiting (16 to 18 percent, compared with 2 percent taking a placebo) Nerve issues (2 to 4 percent, compared with none taking a placebo) Between 2 and 5 percent of participants on retatrutide stopped taking it before the trial ended, with a greater risk of stopping among those who took the highest dose

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Trpm5 transgene inheritance was confirmed by PCR (primers in ESM Table 3

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