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NKTCL cell lines treated with ARQ197, an ATP-non-competitive selective c-MET inhibitor which is currently in phase 3 clinical trials in NSCLC patients, reduced the proliferative response by approximately 50% in two of three cell lines, indicating that the HGF/c-MET signaling is partly responsible for NKTCL proliferation [49]

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Body-mass index and risk of obesity-related complex multimorbidity: an observational multicohort study

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Its use in the UK is therefore effectively restricted to clinical trial settings

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