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31 These studies have demonstrated a steep decreasing gradient of oxygen from the lens periphery to the center

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Specifically, certain strains of Metschnikowia pulcherrima have shown interesting results both for preventing the development of spoilage microorganisms [37, 46] and for protecting against browning [27, 47]

Notably, the pharmacological inhibition of HDAC1 and HDAC2 mitigates the increased expression of EGR1 mediate by cAMP response element-binding protein (CREB)