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Hives usually cause itching, but may also burn or sting

Mitochondria, which play a critical role in energy supply, fat oxidation, ammonia-urea detoxification, anti-oxidant defense, and apoptosis, is known to be a major site of ROS production while mitochondrial proteins are known to be major targets of increased oxidative/nitrosative stress upon exposure to toxic compounds and/or in pathophysiological conditions [41, 42, 43]

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The animals were placed in an induction chamber with an oxygen-enriched environment, with the initial induction concentration set at 4%5% isoflurane, until deep anesthesia signs such as loss of the righting reflex appeared, after which maintenance was initiated