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A subsequent 24-week Phase IIb study with 536 subjects found no statistically significant weight-loss difference , leading to termination of development in 2007

These structural differences are the basis for comparative structure-activity relationship studies examining how substitution pattern influences adrenergic receptor subtype selectivity and binding affinity across the phenylethanolamine compound series.

In WT mice, both AOD9604 and hGH elevated plasma glycerol levels, indicating enhanced lipolytic activity

Nebulised adrenaline, used for upper airway oedema causing stridor, may be absorbed and can lead to significant tachycardia, arrhythmias and hypertension, although catecholamines are readily metabolised by lung tissue

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