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They compared both patients on thyroxin substitution and patients not on thyroxine substitution

Direct mechanisms of tirzepatide on cardiovascular health Although the precise mechanism by which tirzepatide could benefit HF is not known, several potential pathways have been suggested: Anti-inflammatory effects Patients with T2DM experience increased levels of hyperinsulinemia, hyperglycemia, and insulin resistance

Reducing to a lower maintenance dose (instead of escalating) allows continued weight loss benefits while minimizing GI distress

We often see patients whove had great success on medications like Ozempic or Wegovy but are left with loose skin or uneven fat distribution