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Int J Mol Sci 23(9):4611 Zhai X, Jia M, Chen L, Zheng CJ, Rahman K, Han T, Qin LP (2017) The regulatory mechanism of fungal elicitor-induced secondary metabolite biosynthesis in medicinal plants
A 2011 systematic review of clinical data suggested that citicoline could hasten the resorption of cerebral edema and improve the recovery of consciousness and neurologic disorders in severe TBI cases (classified by Glasgow Coma Scale [GCS] scores of 8) (5)
All human cells are capable of producing glutathione and do, but the primary synthesis site is the liver, which manufactures glutathione following intake of the necessary precursor ingredients (amino acids)
Future trials should prioritize adaptive designs to evaluate combinations (e.g., NOX inhibitors + Nrf2 activators) and digital health tools (e.g., continuous glucose/BP monitoring) for dynamic OS assessment
