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The increased presence of MT1 receptor activity in people with major depressive disorder indicates that this receptor type could be a potential target for alleviating some symptoms of depression (Wu et al

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CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons

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This receptor activation leads to a rapid burst of growth hormone release