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Pancreatitis represents one of the most concerning potential complications

Clinical context matters: what is safe for a healthy outpatient is not safe for a critically ill or severely immunocompromised patient

It is important to understand the distinction

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Malonyl-CoA generated by acetyl-CoA carboxylase - isoform 2 (ACC2) binds with high affinity to each of the CPTI isoforms and acts like a switch to control the sensitivity to this key inhibitory molecule and regulate the transfer of fatty acids into the mitochondrial matrix and thence their oxidation