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The normalization of Bcl-2 expression may indicate reduced cellular stress and improved tissue homeostasis

5-Amino-1MQ is sold under research-use-only labeling and is not an FDA-approved treatment

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doi: 10.1038/s41422-020-00441-1 6 DixonSJLembergKMLamprechtMRSkoutaRZaitsevEMGleasonCEet al

Given the substantial resource demands of drug development, large sample sizes, extended trial durations, and the financial and physiological burden of certain treatments (e.g., monoclonal antibodies targeting A), it is ethically and scientifically imperative to identify patients for whom benefit is plausible and to avoid unnecessary exposure of those unlikely to respond