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The adjustments are as follows: (1) For simplicity, we treat cytosolic serine and glycine as constant

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The future of longevity medicine increasingly emphasizes interventions that support cellular health and prevent age-related decline rather than merely managing disease after it develops

Iron overload induces M1 polarization, as confirmed by studies showing increased M1 markers, such as IL-6, TNF-, and IL-1, with a concurrent reduction in M2 markers, including tissue transglutaminase 2 (TGM2), effectively promoting M1-type macrophage polarization (97)

Over time, this leads to lighter pigmentation, more even skin tone, and enhanced radiance