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For instance, under depletion or low glucose concentrations, cells undergo a metabolic switch from aerobic glycolysis to respiratory growth and hexokinase II (HKII), the mitochondria-located enzyme that catalyzes the first step of glycolysis, binds to mTORC1 to inhibit its downstream signaling and induce autophagy 13

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To move beyond basic cell culture, the study incorporated ex vivo skin models

While men typically produce higher levels of testosterone, women also need this hormone in balanced amounts for muscle maintenance, mood regulation, bone health, and metabolism