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Piperlongumine Piperlongumine (PL) is an alkaloid isolated from Piper species, commonly used in traditional medicine in particular in Asia and Latin America that in recent years has been extensively studied because of its anti-cancer potential, being able to inhibit proliferation in several cancer cell lines 107

Therefore, it is require to implement actions that will allow to control cardiovascular risk factors, including being overweight or obese

Coskun and colleagues (Cell Metabolism, 2022) provided the foundational characterisation, demonstrating that balanced engagement of all three receptors produces metabolic effects not achievable through dual or single-receptor pharmacology alone

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Metabolic rewiring in the promotion of cancer metastasis: Mechanisms and therapeutic implications