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Skin Repair and Extracellular Matrix Research Copper serves as an essential cofactor for numerous enzymes involved in collagen synthesis, antioxidant defense, and connective tissue maintenance

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Although both oxidized and antioxidant levels of lipids are higher in RA-FLS than in healthy controls, the increase in antioxidant levels is slightly higher than that of oxidation, indicating that RA-FLS is resistant to ferroptosis (48)

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