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(PubMed)
Discussion GLP-1 RAs have demonstrated immuno-modulatory effects, presenting a promising therapeutic potential in psoriasis and HS
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Commonly prescribed GLP-1RA include Semaglutide (Ozempic , Rybelsus ), Dulaglutide (Trulicity ), Liraglutide (Victoza , Saxenda ), and Exenatide (Byetta , Bydureon ) (Table 1)
4.2 Promotion of insulin secretion GLP-1 stimulates insulin secretion in a glucose-dependent manner through specific receptors expressed on pancreatic cells.GLP-1R is a family of secretins (class B) that couples GLP-1 to downstream cell responses, and conformational changes in the receptor upon ligand binding facilitate the interaction between its intracellular region and signaling proteins (Jones et al., 2018)
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