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Deterioration of the incretin effect leads to a decreased ability to secrete insulin and hyperglycemia, which may exacerbate insulin resistance [14]

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It is important to maintain adequate fluid intake when using osmotic laxatives, as they require sufficient water to function effectively

Protocol 3: the twice-weekly split dose approach Goal: Flatten the concentration curve to eliminate end-of-week symptom return Schedule (any compounded GLP-1): Take half your weekly dose every 3.5 days (e.g., Monday morning and Thursday evening) Total weekly dose remains identical Escalate total weekly dose at the same rate as your original plan Why the plotter supports this: The plotter shows a dramatic difference between once-weekly and twice-weekly dosing curves at the same total weekly dose

Circulatory Changes The glucagon effect (especially in newer multi-agonists) may alter blood flow in ways that are not yet fully understood