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This rapid clearance might suggest the need for larger doses, yet the peptide initiates cellular processes that continue long after the compound itself has been metabolized

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doi: 10.1016/j.biopha.2022.113395 161 van de DonkNRichardsonPGMalavasiF

MRS Bulletin

It is also noteworthy that as well as stimulating release of aldosterone, angiotensin II can also mediate kidney fibrosis independently of aldosterone [70] and may also cause damage to podocytes [71], so RAAS inhibitors are also helpful in this regard

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