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The author Z-BJ declared that they were an editorial board member of Frontiers, at the time of submission

In contrast, Exos derived from cancer cells are being investigated for their potential selectively to induce ferroptosis in tumors

Okamoto M

These findings, consistent with the unchanged levels of key proteins detected by Western blot, indicated that PPARa likely does not exert its anti-ferroptotic effects through common mechanisms such as modulating PUFA-PL synthesis, the cyst(e)ine-GSH-GPX4 axis, or iron transport to inhibit the Fenton reaction

The reaction catalyzed by carbamoyl phosphate synthetase I is the regulatory enzyme of the pathway