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If you are vomiting multiple times per day and it does not improve after 48 hours, your dose is too high

doi:10.1093/ajcn/75.2.295

The slowing of gastric motility is dose-dependent and represents both a therapeutic benefit and a potential source of gastrointestinal adverse effects

The drug has become so popular that it's been in short supply for much of the past year

For adults with a BMI of 40 kg/m2 or higher or those with a BMI of 35 kg/m2 or higher with obstructive sleep apnea or prediabetes, Apovian recommends strongly considering bariatric surgery as a first-line therapy due to very low complication rates and robust and durable weight loss