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Most patients can expect to lose 10% to 20% of their initial body weight over 12 to 18 months when using therapeutic doses of semaglutide or tirzepatide, with weight loss plateauing after this period

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N., Turkson, B

The Triple-Agonist Mechanism Energy Expenditure: Studied via glucagon receptor pathways Insulin Secretion: GLP-1 and GIP mediated signaling Lipid Metabolism: Adipose tissue and hepatic fat models For a mechanistic comparison, see: Retatrutide vs Tirzepatide Research Comparison

the apparent high incidence should be interpreted cautiously given the small denominator and high baseline AKI risk in advanced CKD