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Interestingly, the SUSTAIN program showed for the first time that GLP-1RA might induce an acute drop in the eGFR slope resembling the pattern observed in established nephroprotective drugs such as SGLT-2i, angiotensin-converting enzyme inhibitors (ACE-I) and angiotensin receptor blockers (ARBs) [17]

The pharmacokinetic properties of semaglutide, while favorable for once-weekly dosing due to its extended half-life, were specifically optimized for this interval to maintain therapeutic drug levels

Acute gallbladder disease In trials for Mounjaro, 0.6% of participants reported gallbladder disease including gallstones, gallbladder inflammation, biliary colic (intermittent or constant abdominal pain), and cholecystectomy (surgical removal of the gallbladder)compared to 0% in the placebo group

The three most common are 5mg/mL, 10mg/mL, and 20mg/mL