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Finally, epigenetic regulatory networks are incompletely characterized: while individual ubiquitinases, miRNAs, or demethylases are implicated, the integrated epigenetic landscape governing ferroptosis in I/R AKI (e.g., crosstalk between ubiquitination and miRNA-mediated silencing, or epigenetic memory of ferroptosis susceptibility) remains unclear

Patients considering compounded medications should discuss these specific risks, potential benefits, quality assurance procedures, and alternative options with qualified healthcare providers before proceeding with treatment

Ethics statement The animal study was reviewed and approved by the Ethics Committee of Third Xiangya Hospital, Central South University

Wegovy (semaglutide) injection is a well known drug that IS approved by the U.S Food and Drug Administration (2021) for chronic weight management in adults with obesity or are overweight

BODIPY LPO assay In total, 250,000 HeLa cells per well were seeded into six-well plates in DMEM (10% FCS) or FluoroBrite (2% FCS)