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Naunyn Schmiedebergs Arch Pharmacol 393:14051417 Abolmaali SS, Tamaddon AM, Dinarvand R (2013) A review of therapeutic challenges and achievements of methotrexate delivery systems for treatment of cancer and rheumatoid arthritis

Bacteriostatic water contains benzyl alcohol as a preservative

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doi: 10.1111/j.1468-2982.2007.01288.x 2

Concentration after reconstitution is just division: concentration (mg/mL) = vial load (mg) bac water added (mL) A 5 mg vial reconstituted with 2 mL of bac water yields 2.5 mg/mL