However, reaching these doses needs careful titration over 20 weeks to minimize gut side effects
Marchetti P, Decaudin D, Macho A, Zamzami N, Hirsch T, Susin SA et al
A practical heuristic: if youre set on using a modified form, the more conservative middle-ground protocols (1 mg/day for 20 days for N-acetyl amidate, or 1-2 mg for amidate alone) sit closer to the dose math that would be theoretically equivalent to the base epithalon protocols if the modifications deliver something like 5-10x bioavailability improvement
The one place it shows up in the real world is cheating Dermorphin gained public notice when it was found being injected into racehorses as an illicit analgesic to mask pain and boost performance
In children 6 months to less than 12 years of age, DUPIXENT should be given by a caregiver