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Jacobs, P et al

To be accepted as a surrogate endpoint, a biomarker must demonstrate that changes in its levels reliably and reproducibly predict clinical benefit across multiple interventions and study populations, an evidentiary standard that few neurodegeneration-related markers currently meet [583]

Another 34 percent reported eating less often and 30 percent said they were moving toward smaller quantities

Meaningful weight loss generally requires reaching at least the 1.0 mg weekly dose, which takes about 8 weeks with standard titration

Conclusion In this real-world study, the response to RIM for the acute treatment of migraine was consistently favorable at the population level and in individual participants