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Microneedle introduction, liposome encapsulation or chemical penetration enhancers (such as azone) can increase its transdermal absorption rate to 15%-25%, bringing the local concentration to the effective threshold (5-10 mM)

Diabetes Obes Metab 22(10):18861891

Fehse F, Trautmann ME, Holst JJ, Halseth AE, Fineman M, Kim D, Nauck MA

10.1021/nl402628n 87 HuangY

How often do you experience side effects when taking medications (regularly/sometimes/never), do you worry about side effects like nausea, fatigue, vomiting, constipation, or diarrhea (Y/N), and how impactful would those side effects be on your daily life (very/somewhat/not impactful)