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A trial protocol may study a different population, dose range, or endpoint
Le May C, Berger J, Lespine A, Pillot B, Prieur X, Letessier E, Hussain M, Collet X, Cariou B, Costet P
(PubMed) Ye Z, Song H
Patients with existing chronic kidney disease face higher risk of acute kidney injury if dehydration develops
Rather than observing increasing and persistent JNK activation (persistent pJNK), rising ROS levels, peroxynitrite formation, and release of Endo G and AIF, instead they found pJNK decreased over time to undetectable levels, and hepatic necrosis was prevented ( Figure 22 )
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