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Hyperglycemia drives the accumulation of advanced glycation end products AGEs, which activate the RAGE/MAPK signaling axis, thereby inhibiting Col-II synthesis and promoting a catabolic state in chondrocytes (31)

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Amylin was identified in the 1980s as a peptide co-secreted with insulin by the pancreatic beta cells, and researchers recognized early that it contributes to satiety and glucose regulation