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84 The topical application of vasodilators provides pain relief in PDPN, suggesting a role for hypoxia and/or vascular dysfunction in the generation of neuropathic pain in DPN

PMID: 38605953 J Invest Dermatol 2023 Dec;143(12):2366-2377.e7

It also further corroborated the role of ALDH7A1 and the reason for the reduction of MDA content [71]

Beyond A clearance, astrocytes also display resilience to proteotoxic stress by activating protective pathways, including glutathione synthesis and heat shock protein expression

However, to maintain the normal operation of the immune system, it is necessary to fully activate the immune cells to differentiate