For patients who are not well-controlled on a treatment with metformin and basal insulin, a treatment intensification with a DPP-4 inhibitor may be feasible
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2011 doi: 10.3945/ajcn.110.003483
Remarkably, it was shown that a single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) raised the mRNA levels of POMC and the aryl hydrocarbon receptor (AhR), which in turn caused higher cortisol levels 96
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