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1A) had been reported to potentiate GLP-1R-mediated cAMP signaling in response to weak peptidic agonists, including the GLP-1 metabolite GLP-1(936)amide ( 21 ) and the GLP-1R/glucagon-receptor dual agonist oxyntomodulin ( 22 )

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Use proper needle technique by pinching the skin, inserting the needle at a 90 angle (or 45 if your skin is very thin), and choosing smaller-gauge needles for less discomfort

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