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Description

It is renowned in clinical research for its ability to bypass the need for physical exertion to activate the AMP-activated protein kinase (AMPK) pathway

doi: 10.1111/j.1365-2672.1998.tb05269.x 49 VillegasM

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MANF reduces the expression of the pro-apoptotic factor CHOP by inhibiting the nuclear translocation of activating transcription factor 6 (ATF6), downregulating the generation of the XBP1s splice variant, and blocking activation of the PERK-eIF2 pathway [146]