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Cystine deprivation induced GSH efflux and extracellular degradation, which aimed to restore cellular cysteine
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KobayashiHGil-GuzmanEMahranAMSharmaRKNelsonDRThomasAJet al
When IGF-1 axis is activated, multiple signaling pathways corresponding to its kinase domain are also activated, including PI3K/Akt pathway and Raf/MEK/ERK level linkage pathway, which can ultimately reduce IR and prevent cell apoptosis (58, 59), thereby improving NAFLD
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