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However, IGF-1 does not directly stimulate lipolysis the way growth hormone does

2.3.2 Other ferroptosis-associated axes Although GSH/GPX4, ACSL4, and PUFA are the main factors required for ferroptosis, exogenous oxygen radicals generated by photodynamic therapy (PDT) can directly peroxidize PUFAs and initiate lipid autoxidation, triggering ferroptosis-like cell death by means independent of LOXs and ACSL4 (53)

This is especially important with GLP-1 medications because the effects can be subtle at first

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These results combined suggest that our assembloid model with excess mesenchyme mimics some aspects of human biliary fibrosis as seen in cholangiopathies, including PSC and PBC