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What to monitor If you are taking levothyroxine and experience significant weight loss on a GLP-1 medication, your thyroid hormone requirements may change
Punjabi M, Arnold M, Geary N, Langhans W, Pacheco-Lpez G
Because tirzepatide also acts on the GLP-1 pathway, it slows gastric emptying in much the same way, so the gut side effects tend to look familiar
These findings are intriguing but do not yet constitute definitive clinical guidance
Common step therapy requirements include trying metformin first (if type 2 diabetes is present), trialing a GLP-1 single-agonist like semaglutide (Ozempic or Wegovy) before moving to the dual-agonist tirzepatide, and documenting inadequate response or intolerable side effects on the prior medication
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